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Nitric oxide then activates the enzyme guanylate cyclase, which ends up in elevated amounts of cyclic guanosine monophosphate (cGMP), making smooth muscle mass leisure inside the corpus cavernosum and allowing for inflow of blood .
Tadalafil experienced no important effect on the pharmacokinetics of theophylline.When tadalafil was administered to subjects taking theophylline, a small augmentation (three beats per moment) of the rise in heart level associated with theophylline was noticed.
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